Epetraborole hydrochloride

Research use only, not for human use.

Epetraborole (GSK2251052, AN3365) is a broad-spectrum antibacterial inhibitor of leucyl tRNA-synthetase (LeuRS).

Epetraborole (GSK2251052, AN3365) is a broad-spectrum antibacterial inhibitor of leucyl tRNA-synthetase (LeuRS), shows MIC50/MIC90 of 2/4 ug/ml against 916 clinical anaerobic isolates; MIC90s against 302 Bacteroides fragilis and Bacteroides thetaiotaomicron strains are 4 and 8 μg/ml, respectively; a single amino acid polymorphism (P329) within the editing domain of LeuRS reduces susceptibility to GSK2251052.Bacterial Infection Phase 2 Discontinued

Epetraborole (0-32 μg/mL) shows anti-bacterial activity against key gram-negative aerobic and anaerobic pathogens and gram-positive anaerobes. Cell Viability Assay Cell Line:Anaerobes isolates Concentration:0-32 μg/mL Incubation Time:Result:Showed MIC50/MIC90 for all anaerobes isolates tested of 2 and 4 μg/mL, respectively.

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GSK2251052 hydrochloride | AN3365

GPCR/G Protein

Antibacterial

bacterialleucyltRNAsynthetase

Infection

Bacterial Infection

1234563-16-6

273.521

C11H17BClNO4

>98% (HPLC)

H2O: ≥ 28 mg/mL

B1(C2=C(C=CC=C2OCCCO)C(O1)CN)O.Cl

1-Propanol, 3-[[(3S)-3-(aminomethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaborol-7-yl]oxy]-, hydrochloride (1:1)

(-20℃)

With Ice Pack

≥ 2 years